Toleranse innebærer at regelmessig bruk av vanedannende legemidler above four-6 uker gjør at kroppen venner seg til virkningen og du får gradvis mindre effekt av legemidlet.Protracted withdrawal signs might final months to in excess of 12 months. As a result, there might be problems in differentiating withdrawal indications from probable re-emer

Extensive accumulation of diazepam and its major metabolite, desmethyldiazepam, has become observed next Long-term administration of diazepam in healthful aged male topics. Metabolites of the drug are regarded to be significantly excreted with the kidney, and the risk of poisonous reactions can be greater in sufferers with impaired renal functional